Fig. 2.

Human liver microsome activity against UGT2B17 substrates by sex and genotype. Glucuronidation assays were performed against three UGT2B17 substrates as described previously (Balliet et al., 2009; Sun et al., 2010; G. Chen, N. Giambrone, R. M. Balliet, and P. Lazarus, submitted for publication). Sex [female (F) and male (M)] and UGT2B17 deletion genotype [(+/+), (+/0), and (0/0)] are shown on the x-axis. The y-axis displays HLM glucuronidation activity against 17-DHE (A), 3-HC (B), and SAHA (C). Only significant comparisons are shown (p < 0.05).