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UCL2077 differentially alters the conductance-to-voltage relationships of KCNQ channels. Conductance-to-voltage relationship for KCNQ2 (A; n = 6), KCNQ3 (B; n = 7), KCNQ4 (C; n = 6), and KCNQ5 (D, n = 6) were obtained from tail currents at −55 mV in the presence (■) and absence (□) of 3 μM UCL2077. B, inset, representative KCNQ3 currents at −50, −40, or −30 mV test potentials in the absence (black) and presence (gray) of 3 μM UCL2077. *, p < 0.05, **, p < 0.01.
