UCL2077 differentially alters the conductance-to-voltage relationships of
KCNQ channels. Conductance-to-voltage relationship for KCNQ2 (A;
n = 6), KCNQ3 (B; n = 7), KCNQ4 (C;
n = 6), and KCNQ5 (D, n = 6) were
obtained from tail currents at −55 mV in the presence
(■) and absence (□) of 3 μM UCL2077. B,
inset, representative KCNQ3 currents at −50, −40, or
−30 mV test potentials in the absence (black) and presence
(gray) of 3 μM UCL2077. *, p <
0.05, **, p < 0.01.