Skip to main content
. 2010 Dec;78(6):1105–1123. doi: 10.1124/mol.110.067207

Fig. 7.

Fig. 7.

VU0285683 dose-dependently decreases marble-burying to a level comparable with that of MTEP. Dose-response curves for the effects of MTEP (A) and VU0285683 (B). The data are the mean number of marbles buried when tested with vehicle and 3, 5.6, 10, and 15 mg/kg MTEP or 3, 5.6, and 10 mg/kg VU0285683 during a 30-min test session. Each value represents the mean + S.E.M. for 9 to 11 animals. The vehicle-treated group buried approximately nine marbles over the 30-min time course. The positive comparator MTEP produced a significant inhibition of marble-burying behavior at a dose of 10 mg/kg (p < 0.005) and 15 mg/kg (p < 0.0001). VU0285683 dose-dependently inhibited marble burying over the course of the 30-min interval, significant at a dose of 10 mg/kg VU0285683 (p = 0.0001).