TABLE 2.
Chemical optimization of VU0040228
| R | R1 | R2 | IC50 | |
|---|---|---|---|---|
| nM | ||||
| VU0255038 | H | H | CF3 | 2360 ± 156 |
| VU0255036 | H | F | CN | 6310 ± 329 |
| VU0067144 | H | H | Cl | 240 ± 54 |
| VU0255037 | H | H | Br | 215 ± 29 |
| VU0285683 | F | H | CN | 24.4 ± 3.6 |
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