Table 7.
Recipient Survival After Fully Allogeneic Small Bowel Transplantation With Immunosuppression (Published Through 1993)
| Strain Combinations | ||||
|---|---|---|---|---|
| Recipient | Donor | Immunosuppression | Survival (d) | Reference(s) |
| LEW | ACI | CyA 15 mg/kg/d, IM (d 0–>28) | 130.3 | 39 |
| CyA 40 mg/kg/d, IM (d −2–>7) | 34.3 | 47 | ||
| FK 506 0.1–0.5 mg/kg/d, IM (d 0–>29) | 13.6–34.6 | 45 | ||
| FK 506 2.0->1.0 mg/kg/d, IM (d 0–>30) | 50.6 | 47 | ||
| LEW | BN | CyA 5 mg/kg/d, IM (d 0–>13) | > 100 | 41 |
| CyA 15 mg/kg/d, IM (d 0–>28) | > 360 | 38, 39 | ||
| CyA 15 mg/kg/d, IM (d 0–>6) | > 200 | 53 | ||
| FK 506 0.15 mg/kg/d, IM (d 0–>13) | 42.0 | 1 | ||
| FK 506 0.32–0.64 mg/kg/d, IM (d 0–>13) | > 100 | 1, 6, 11 | ||
| FK 506 2.0 mg/kg/d, IM (d 0–>4) | > 180 | 38 | ||
| RS 61443 30 mg/kg/d, PO (d 0–>6) | 10.7 | 46 | ||
| Rapamycin 0.8–1.6 mg/kg/d, civ (d 0–> 13) | 21.6–31.0 | 48 | ||
| LEW | F344 | CyA 30 mg/kg/d, IM (d 0–> 13) | > 150 | 40 |
| FK 506 0.32 mg/kg/d, IM (d 0–>13) | > 150 | 40 | ||
| Deoxyspergualin 3 mg/kg/d, IM (d 0–>11) | > 80 | 40 | ||
| BN | LEW | FK 506 0.15–1.0 mg/kg/d, IM (d 0–>13) | 22.5–28.5 (GVHD) | 1 |
| BN | WAG | CyA 5–25 mg/kg/d, IM (d 0, 1, 2, 4, 6) | 18.7–92.7 (GVHD) | 13, 50 |
| FK 506 2.0 mg/kg/d, IM (d 0, 1, 2, 4, 6) | 28.5 (GVHD) | 49 | ||
| Rapamycin 1.0 mg/kg/d, IM (d 0, 1, 2, 4, 6) | 10.0 | 50 | ||
| WAG | BN | CyA 5–25 mg/kg/d, IM (d 0, 1, 2, 4, 6) | 9.6–200 | 13 |
| Rapamycin 1.0 mg/kg/d, IM (d 0, 1, 2, 4, 6) | 11.3 | 50 | ||
| WFu | BUF | Rapamycin 0.8 mg/kg/d, civ (d 0–>13) | 25.0 | 48 |
| PVG | DA | CyA 15 mg/kg/d, IM | > 100 | 44 |
| DA | PVG | CyA 15 mg/kg/d, PO | > 56 | 54 |
Abbreviations: CyA, cyclosporine A; IM, intramuscular injection; PO, oral administration; civ, continuous intravenous infusion.