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Dose-dependent effects of DOI on head-twitch behavior in NIH Swiss mice at the University of Michigan (●), the Yerkes National Primate Research Center (□), and the University of Arkansas for Medical Sciences (■). Abscissa, dose of DOI expressed in milligrams per kilogram on a log scale. Ordinate, mean head twitches recorded over a 10-min observation period. Asterisks indicate significant differences among groups.
