TABLE 1.

Concentrations of 10074-G5 in plasma and tissues after administration of 20 mg/kg 10074-G5 intravenously to C.B-17 SCID female mice bearing Daudi xenografts

Time	Plasma	Tumor	Liver	Kidney	Lung	Spleen	Heart	Brain	Skeletal Muscles	Red Blood Cells	Fat
min	nmol/ml	nmol/g	nmol/g	nmol/g	nmol/g	nmol/g	nmol/g	nmol/g	nmol/g	nmol/mlg	nmol/g
5	58.46 ± 2.73	5.61 ± 1.23	40.81 ± 8.71	29.26 ± 7.74	44.29 ± 8.18	7.95 ± 0.60	22.00 ± 3.48	16.76 ± 3.33	8.25 ± 0.83	13.64 ± 3.77	10.87 ± 1.52
10	20.98 ± 6.54	5.16 ± 1.18	22.92 ± 18.86	17.67 ± 6.31	40.37 ± 5.43	6.49 ± 1.97	11.44 ± 1.86	6.83 ± 2.40	5.39 ± 2.07	3.14 ± 2.07	10.09 ± 1.48
15	15.11 ± 3.37	5.12 ± 1.11	10.36 ± 4.18	5.28 ± 0.15	26.34 ± 0.10	2.88 ± 0.32	8.34 ± 2.25	3.30 ± 0.35	4.73 ± 1.11	2.68 ± 0.39	18.38 ± 5.01
30	6.66 ± 2.94	1.44 ± 0.76	6.71 ± 0.12	1.77 ± 0.15	12.36 ± 0.97	1.20 ± 0.12	2.53 ± 0.20	1.06 ± 0.21	2.75 ± 0.81	0.48 ± 0.17	19.30 ± 7.05
60	1.85 ± 0.37	1.47 ± 0.78	5.74 ± 0.68	1.04 ± 0.27	3.59 ± 1.57	0.89 ± 0.42	0.92 ± 0.22	0.52 ± 0.02	1.02 ± 0.45	0.19 ± 0.11	6.83 ± 4.03
120	1.05 ± 0.11	0.29 ± 0.03	3.33 ± 2.63	0.24 ± 0.04	3.08 ± 1.11	ND	0.52 ± 0.14	0.31 ± 0.02	0.68 ± 0.27	0.06 ± 0.00	4.59 ± 0.29
240	0.39 ± 0.19	ND	1.25 ± 0.32	0.21 ± 0.03	0.67 ± 0.12	ND	ND	0.04 ± 0.00	ND	ND	0.91 ± 0.46
360	ND	ND	0.65 ± 0.03	ND	ND	ND	ND	ND	ND	ND	ND
1020	ND	ND	0.42 ± 0.07	ND	ND	ND	ND	ND	ND	ND	ND
1440	ND	ND	0.49 ± 0.08	ND	ND	ND	ND	ND	ND	ND	ND
t 1/2	37	29	—	—	—	—	—	—	—	—	—
AUC0→∞ a	864 (899)	223 (212)	1819 (1864)	621 (681)	1063 (1232)	147 (141)	349 (380)	216 (228)	255 (244)	131 (132)	1541 (1584)

ND, not determined.

^a AUCs were calculated noncompartmentally using both the Lagrange function and the Trapezoidal method (in parentheses). AUC units are nanomoles per milliliter per minute for plasma and nanomoles per gram per minute for tissues.