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Effect of UKCP-110 alone and in combination with methamphetamine on DA (top left) and DOPAC (top right) fractional release and total methamphetamine-evoked DA overflow (bottom). The arrows indicate the point in time at which analog was added to the superfusion buffer and analog remained in the buffer until the end of the experiment. METH was added to the buffer for 15 min as indicated by the brackets. Data are mean ± S.E.M pg/ml/mg slice weight (n = 6).
