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Effect of UKCP-110 on the number of methamphetamine infusions (top) and time course of methamphetamine self-administration (bottom). UKCP-110 dose-dependently decreased the number of METH infusions (0.03 mg/kg/infusion) over the 60-min session. Total and cumulative METH infusions earned in 5-min blocks are presented as mean ± S.E.M. *, different from saline (n = 6).
