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. 2010 Nov 22;120(12):4388–4398. doi: 10.1172/JCI32726

Figure 3. Blunted inotropic responses to Iso in RyR2-S2808A+/+ mice in the absence and presence of 10 Hz pacing.

Figure 3

Iso dose-dependent enhancement of cardiac contractility in WT versus RyR2-S2808A+/+ mice, with or without heart rate control (via right ventricular pacing). Cardiac contractility measured in vivo by left ventricular catheterization in WT (n = 6) versus RyR2-S2808A+/+ mice (n = 7). (A) Cardiac contractility measured without RV pacing. The top panel shows dP/dtmax, and bottom panel shows the percentage change in dP/dtmax. (B) Cardiac contractility measured with RV pacing at 10 Hz (heart rate = 600 bpm). *P < 0.05 versus WT.