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Contractility measurements of WT (n = 7) and RyR2-S2808A+/+ (n = 9) isolated hearts in the absence and presence of 100 nM Iso. (A) Representative traces of left ventricular pressure before and during Iso infusion, demonstrating blunted developed pressure response to Iso in the RyR2-S2808A+/+ hearts (B) Quantitative summary of dP/dtmax (*P < 0.01).
