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. 2010 Nov 22;120(12):4375–4387. doi: 10.1172/JCI37649

Figure 1. Age-dependent cardiomyopathy in RyR2-S2808D+/+ mice.

Figure 1

(A–C) Serial echocardiographic measurements were performed from 2 to 12 months of age in RyR2-S2808D+/+ (S2808D) mice and WT littermates. Compared with WT littermates, RyR2-S2808D+/+ mice exhibited progressive cardiac dysfunction and LV enlargement. LVEDD, LV end-diastolic diameter (WT, n = 7; RyR2-S2808D+/+, n = 10; #P < 0.01 versus WT; *P < 0.05 versus WT). (D) Cardiac catheterization also revealed age-dependent cardiac dysfunction (*P < 0.05 versus WT; #P < 0.01 versus WT). (E) Chronic Iso treatment in RyR2-S2808D+/+ mice and WT littermates. At 4 months of age, RyR2-S2808D+/+ and WT mice were treated with Iso (30 mg/kg/d) for 4 weeks. Cardiac function was monitored with echocardiography at baseline, 1, 2, and 4 weeks (*P < 0.05 versus RyR2-S2808D+/+ mice). (F) Representative histology of age-matched RyR2-S2808D+/+ and WT littermates (top). Cross section at papillary muscle level. Scale bar: 2 mm. Heart weight to body weight (HW/BW) ratio (bottom). Filled circles represent WT mice; open diamonds represent RyR2-S2808D+/+ mice (*P < 0.05 versus WT).