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. 2010 Nov 22;120(12):4375–4387. doi: 10.1172/JCI37649

Figure 2. RyR2 channel complex remodeling in RyR2-S2808D mice.

Figure 2

(A) Progressive oxidation, Cys-nitrosylation (Cys NO) of cardiac RyR2, and depletion of PDE4D3, calstabin2, PP2A, and PP1 from the cardiac RyR2 complex in the RyR2-S2808D mice. (B) Levels of proteins in the RyR2 complex and levels of oxidation and Cys-nitrosylation were normalized to the total amount of RyR2 (AU). *P < 0.05 versus WT at 1.5 months. (C) Oxidation and Cys-nitrosylation of RyR2 in HF samples. RyR2 immunoprecipitations were performed on hearts from mice with MI and sham-treated mice or on samples from HF and non-HF human heart tissue. (D) Levels of oxidation and Cys-nitrosylation were normalized to the total amount of RyR2 (AU). *P < 0.05 versus normal samples.