Figure 6. S107 improves cardiac function in RyR2-S2808D^+/+ mice.

(A) Echocardiographic measurements during a 10-week treatment period, showing that the S107-treated (20 mg/kg/d via osmotic pump) group exhibited preserved cardiac function compared with the vehicle-treated group (^#P < 0.01 versus vehicle-treated group). (B and C) Cardiac catheterization was performed at the end of study, and both dP/dt_max and (dP/dt_max)/P_id, where P_id indicates the instantaneous developed pressure in mmHg and (s^–1) is the unit of measure for (dP/dt_max)/P_id, showed a significant improvement in S107-treated group (*P < 0.05 versus vehicle-treated group).