Figure 3. Both LXR isoforms are required in CD68⁺ cells in vivo for the maximal induction of Ccr7 gene expression.

Aortic arches from Apoe^–/– mice reconstituted with BM from Apoe^–/–, Nr1h3^–/–Apoe^–/–, or Nr1h2^–/–Apoe^–/– donors were transplanted into WT recipients. CD68⁺ cells were laser captured from the plaques of the indicated donors, and Ccr7 mRNA levels were measured in the isolated RNA by qRT-PCR and normalized to Ppia mRNA. *P < 0.05 versus Apoe^–/–.