Figure 9. High expression of Pit-1 in human ductal invasive carcinomas of the breast correlates with occurrence of distant metastasis.

(A) Representative set of negative and positive (1+, 2+, and 3+) Pit-1 and Snai1 immunodetections in human breast invasive ductal carcinomas. Pit-1 immunopositivity in human pituitary gland was used as positive control. Scale bar: 50 μm. (B) Kaplan-Meier survival curves as a function of the immunostaining expression of Pit-1 in the overall group of patients (n = 110), in the subgroup with node-negative breast cancer (n = 52), and in the subgroup with node-positive breast cancer (n = 58). The median of the immunostaining score values in the overall group of patients (score 35.4) was chosen as the cut-off point for both node-negative and node-positive patient subgroups.