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. 2010 Nov 15;120(12):4410–4414. doi: 10.1172/JCI44213

Figure 2. Trib1 deficiency increases plasma lipid levels in mice.

Figure 2

Chow-fed Trib1–/– mice (n = 8) and littermate controls (Trib1+/+, n = 13) were phenotyped at 8 weeks of age (*P < 0.05, **P < 0.01, ***P < 0.001). (A) Plasma cholesterol and TG were elevated in Trib1–/– mice. VLDL, LDL, and HDL were isolated by sequential ultracentrifugation, and significant increases in cholesterol (B) and TG (C) were observed in VLDL and LDL of Trib1–/– mice. (D) Pooled plasma samples were separated by FPLC, and TG was determined in collected fractions. (E) Trib1–/– mice (n = 4) were injected with 1011 gc AAV_trib1 to reconstitute hepatic expression of Trib1. Plasma TG was measured 2 weeks after injection and the percentage change compared with that in control mice receiving AAV_null.