Skip to main content
. Author manuscript; available in PMC: 2010 Nov 29.
Published in final edited form as: Hepatology. 2008 Dec;48(6):1942–1953. doi: 10.1002/hep.22541

Figure 5. Caspase-3 activation requires Bid when primary hepatocytes are treated with TNFα/ActD instead of FasL (± ActD).

Figure 5

Figure 5

(A,B) Fluorogenic caspase-3/-7 activity assay on cytosolic extracts of wt and Bid−/− (A) or wt and XIAP−/− (B) primary mouse hepatocytes treated for the indicated times with 25 ng/mL TNFα plus 0.4 μ-g/mL ActD, 50 ng/mL N2A FasL plus 0.4 μ-g/mL ActD or TNFα and ActD alone. The values represent the means of three independent experiments ± s.d.