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. 2010 Dec 1;21(23):4130–4140. doi: 10.1091/mbc.E10-01-0022

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© 2010 by The American Society for Cell Biology

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 7. — Model of how Arf1, Arf4, and PLA2G6-A control ERGIC morphology. (A) Under steady-state conditions, ERGIC clusters (yellow) sort anterograde cargo (red) into anterograde carriers (AC) directed to the Golgi (red arrows) from retrograde cargo (green) into retrograde carriers (RC) directed to the ER (green arrows). Arf1 binds to PLA2G6-A, thus suppressing generation of ERGIC tubules. (B) Upon Arf1+Arf4 knockdown (or during rewarming from a 16°C block), PLA2G6-A becomes activated and changes the lipid composition of ERGIC membranes leading to tubules connecting ERGIC clusters. Cargo is transported via these tubules to ERGIC clusters that are still sorting-competent. ERGIC tubules move along microtubules (MT).