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. 2010 Dec 1;21(23):4227–4239. doi: 10.1091/mbc.E10-05-0449

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© 2010 by The American Society for Cell Biology

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 7. — RNF4 does not affect PML trafficking between PML and nucleoplasm. (A–C) Effect of RNF4 on PML mobility. (A) FRAP experiments were performed on HeLa PML-YFP stable cells transfected with a nontarget siRNA (siNT) or an siRNA against RNF4 (siRNF4). Images represent projection of z-sections of PML NBs before and after photobleaching over a period of 10 min. Bar, 5 μM. (B) Depletion of RNF4 was controled by SDS PAGE followed by Western blot with rabbit RNF4 antibody. (C) The graph shows the mean values and standard deviations of relative prebleach and postbleach intensities of ten PML Nbs as described in Figure 6.