Table 5.
1) BPA measure from same day as semen sample only (n=190)a,d | 2) Geometric Mean BPA from all participants (n=190)b,d | 3) Geometric mean BPA from men with ≥2 BPA measures (n=78)c,d | 4) BPA from same day as semen sample among men with ≥2 BPA measures (n=78)a,d | |||||
---|---|---|---|---|---|---|---|---|
β (95%CI) | p-value | β (95%CI) | p-value | β (95%CI) | p-value | β (95%CI) | p-value | |
Semen Quality | ||||||||
Sperm Countd,e | 0.85 (0.63, 1.14) | 0.27 | 0.92 (0.66, 1.28) | 0.61 | 1.38 (0.90, 2.12) | 0.14 | 0.93 (0.67, 1.30) | 0.66 |
Concentrationd,e | 0.77 (0.60, 1.00) | 0.047 | 0.82 (0.62, 1.09) | 0.17 | 1.23 (0.80, 1.92) | 0.33 | 0.87 (0.64, 1.20) | 0.41 |
Motilityf | -3.70 (-8.12, 0.74) | 0.10 | -2.43 (-7.31, 2.45) | 0.33 | 0.74 (-7.49, 8.97) | 0.86 | -3.92 (-9.98, 2.13) | 0.20 |
Morphologyf | -0.90 (-1.79, -0.004) | 0.049 | -0.73 (-1.70, 0.26) | 0.15 | -0.84 (-2.55, 0.88) | 0.33 | -1.05 (-2.33, 0.23) | 0.11 |
Sperm Motion | ||||||||
VSLf | -1.79 (-4.00, 0.42) | 0.11 | -2.69 (-5.71, 0.35) | 0.08 | -3.78 (-8.75, 1.17) | 0.13 | -3.27 (-6.93, 0.38) | 0.08 |
VCLf | -3.97 (-7.65, -0.27) | 0.04 | -4.55 (-9.62, 0.54) | 0.08 | -2.85 (-11.5, 5.79) | 0.51 | -5.04 (-11.5, 1.43) | 0.12 |
LINf | 0.80 (-0.85, 2.44) | 0.34 | -1.17 (-4.26, 1.92) | 0.46 | -0.38 (-5.14, 4.37) | 0.87 | 0.27 (-3.19, 3.73) | 0.88 |
DNA Damageg | ||||||||
Comet Extentf | 3.99 (-6.43, 14.4) | 0.45 | 8.11 (-3.98, 20.2) | 0.19 | -4.02 (-23.8, 15.8) | 0.69 | -5.47 (-20.0, 8.95) | 0.45 |
TDMf | 1.12 (-2.39, 4.63) | 0.53 | 1.13 (-2.93, 5.20) | 0.58 | -3.18 (-9.17, 2.81) | 0.29 | -0.80 (-5.19, 3.60) | 0.72 |
Tail%f | 3.88 (0.01, 7.74) | 0.048 | 3.65 (0.04, 8.83) | 0.048 | 3.67 (-2.79, 10.1) | 0.26 | 2.88 (-1.73, 7.49) | 0.22 |
Among men with urine sample from same visit as semen sample only. N=190.
Geometric mean of up to 3 repeated urine samples per subject, some of which were collected months after semen sample. N=190.
Geometric mean value among men with at least 2 urine samples. N=78.
Ln-transformations of bisphenol A, total sperm count, and sperm concentration were used. All other variables were modeled untransformed.
Coefficient represents a multiplicative change in sperm concentration for an IQR change in BPA concentration after back-transformation of both sperm concentration and BPA values. For an IQR change in BPA concentration, a coefficient equal to 1.0 indicates no change in sperm concentration, a coefficient < 1.0 indicates a multiplicative decrease in sperm concentration, and a coefficient > 1.0 indicates a multiplicative increase in sperm concentration.
Coefficient represents the change in semen quality parameter or sperm DNA damage measure for an IQR change in urinary BPA concentration after back-transformation of urinary BPA concentration. For an IQR change in BPA concentration, a coefficient equal to 0 indicates no change in semen/sperm measure, a coefficient < 0 indicates a decrease in semen/sperm measure, and a coefficient > 0 indicates an increase in semen/sperm measure.
N=132 for comet assay measures in statistical approaches 1) and 2), N=78 for comet assay measures in approaches 3) and 4).