Table 1. Adult Lifespan Analysis.
| Genotype | Median LS ±STDEV | p-value vs. wild type | Sample size n(censored) | Replicates N | |
|---|---|---|---|---|---|
| Log-rank | Wilcoxon | ||||
| wild type | 15.9±3.6 | - | - | 404(59) | 8 |
| oga-1(ok1207) | 20.9±4.1 | <0.0001 | <0.0001 | 317(43) | 6 |
| ogt-1(ok1474) | 12.9±1.9 | <0.0001 | <0.0001 | 306(64) | 6 |
| oga-1(ok1207); ogt-1(ok1474) | 15.5±4.9 | 0.030 | 0.040 | 174(35) | 2 |
| daf-2(e1370) | 28.6±3.5 | <0.0001 | <0.0001 | 235(26) | 3 |
| oga-1(ok1207); daf-2(e1370) | 21.6±0.6 | <0.0001 | <0.0001 | 201(20) | 3 |
| ogt-1(ok1474); daf-2(e1370) | 13.2±1.9 | <0.0001 | <0.0001 | 218(28) | 3 |
| daf-16(mu86) | 14.3±2.5 | 0.0001 | <0.0001 | 228(60) | 3 |
| oga-1(ok1207); daf-16(mu86) | 14.8±1.8 | 0.019 | 0.009 | 173(25) | 2 |
| ogt-1(ok1474); daf-16(mu86) | 12.8±0.4 | <0.0001 | <0.0001 | 150(24) | 2 |
| age-1(hx546) | 25.6±4.1 | <0.0001 | <0.0001 | 216(18) | 3 |
| oga-1(ok1207); age-1(hx546) | 24.7±6.8 | <0.0001 | <0.0001 | 241(17) | 3 |
| ogt-1(ok1474); age-1(hx546) | 15.9±1.6 | 0.424 | 0.590 | 258(31) | 3 |
| sgk-1(ok538) | 29.8±3.2 | <0.0001 | <0.0001 | 235(16) | 3 |
| oga-1(ok1207); sgk-1(ok538) | 26.2±2.1 | <0.0001 | <0.0001 | 209(30) | 3 |
| ogt-1(ok1474); sgk-1(ok538) | 16.6±2.3 | 0.343 | 0.375 | 214(39) | 3 |
| pdk-1(mg142)gf | 14.8±1.7 | 0.013 | 0.007 | 334(84) | 5 |
| oga-1(ok1207); pdk-1(mg142) | 18.7±8.1a | <0.0001 | <0.0001 | 284(43) | 5 |
| akt-1(mg144)gf | 11.5±2.1 | <0.0001 | <0.0001 | 205(32) | 2 |
| oga-1(ok1207); akt-1(mg144) | 19.8±4.2b | 0.0002 | 0.0002 | 229(22) | 2 |
a.
pdk-1 vs. oga-1;pdk-1 p-value <0.0001
b.
akt-1 vs. oga-1;akt-1 p-value <0.0001
N = number of replicates; n = pooled animals from N replicate experiments (censored animals were included in the Log-rank/Wilcoxon analysis)