Table 1. HUCB cell treatment alters gene expression in OLs subjected to 24 hrs OGD.

Table shows OL genes for which HUCB cell treatment during OGD caused a fold change ≥ 1.5 compared to non-treated OGD controls. Genes were grouped based on functional relevance, and those associated with OL survival, proliferation, and myelination (bold font) were selected for further investigation.

Genes and Function		Fold Change
Antioxidant/Free Radical Scavenging
Metallothionein 3		1.64
Peroxiredoxin 4		5.27
Lipid Biosynthesis/Myelination
UDF galactosyltransferase 8A		1.68
Insulin induced gene 1		1.71
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1		1.73
Myelin Oligodendrocyte Glycoprotein		1.92
Isopentenyl-diphosphate delta isomerase		2.22
Growth/Proliferation
Rhoa		1.62
Crystallin, alpha B		1.72
U2AF homology motif (UHM) kinase 1		1.97
Integrin linked kinase		1.99
Guanine nucleotide binding protein, alpha o		2.22
Translin-associated factor X		2.96
S 100 calcium binding protein A6 (calcyclin)		3.54
Ret proto-oncogene		3.91
Protein kinase C, beta 1		5.34
lumican		−5.73
Pleckstrin homology-like domain, family A, member 1		−20.77
Structural
Tetraspanin 2		1.54
Actin related protein 2/3 complex, subunit 1A		1.56
Vimentin		1.63
Microtubule-associated protein tau		1.72
Actin related protein 2/3 complex, subunit 1B		1.78
Tropomyosin 1, alpha		2.03
Versican		2.54
Ral GEF with PH domain and SH3 binding motif 2		2.70
Stathmin-like 2		2.73
Microtubule-associated protein 2		5.50
Metabolic
Translocase of inner mitochondrial membrane 8 homolog b (yeast)		1.67
Translocase of inner mitochondrial membrane 10 homolog (yeast)		1.73
Acyl-CoAthioesterase 2		−69.70
Signaling
Endothelial different lysophosphantidic and G-protein-coupled receptor.2		2.46
Phospholipase D1		3.20