Skip to main content
. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Curr Opin Cell Biol. 2010 Dec;22(6):828–836. doi: 10.1016/j.ceb.2010.08.004

Figure 1. Regulation and assembly of cell death platforms.

Figure 1

Schematic summarizing formation of the various cell death platforms discussed. The nematode and human apoptosomes consist of heptameric and octameric rings respectively, which bring together CARD domains to recruit CED-3 and Caspase-9 for proximity-induced activation. The DISC and PIDDosome form clusters of DD, which incorporate adaptor proteins such as FADD and RAIDD that use their CARD and DED domains to recruit and activate Caspase-8/-10 and -2 respectively. TNFα is also able to activate Caspase-8 through a mechanism that remains to be clarified mechanistically.