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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Inherit Metab Dis. 2010 Sep 30;33(6):715–725. doi: 10.1007/s10545-010-9192-5

Figure 2. The DNA sequence of the ALDOB promoter region.

Figure 2

The sequence of human ALDOB from position −246 to +85 is shown with exon 1 capitalized. The start of transcription is indicated with a forward arrow at position +1. Nucleotides within the promoter that are conserved across vertebrates are indicated with an asterisk (*). The boxed sequence represents the TATA box. DNA sequences containing known and proposed cis-elements and their corresponding transcription factors are denoted with brackets under the sequence. Known single nucleotide polymorphisms are indicated with an inverted carrot (v) (from 5′ to 3′: SNP rs35386088, rs12337537, rs17551011, and rs71866381 as defined by NCBI). The novel mutations are indicated with upward arrows showing the nucleotide change.