Table 5.

Cox proportional hazards models for the incidence of dementia and Alzheimer’s Disease according to HT use.

Exposure	N	Incidence of Dementia (n=79 cases)				N	Incidence of Alzheimer’s Disease (n=53 cases)b
		Unadjusted HR [95% CI]	p	Multivariate HR [95% CI]	p		Unadjusted HR [95% CI]	p	Multivariate HR [95% CI]	p
Never use of HT	2169	1		1		2146	1		1
Past use of HT	487	0.76 (0.38–1.51)	0.43	0.74 (0.35–1.55)	0.42	485	0.79 (0.34–1.83)	0.57	0. 39 (0.39–2.23)	0.86
Current use of HT	474	1.04 (0.43–2.50)	0.94	0.83 (0.32–2.17)	0.70	473	1.61 (0.60–4.32)	0.34	1.36 (0.44–4.20)	0.59
Apoe-ε4 + (all women)	3130	2.35 (1.53–3.60)	<0.001	2.27 (1.48–3.49)	<0.001	3104	2.38 (1.42–4.00)	0.001	2.21 (1.31–3.74)	0.003
Apoe-ε4 − & never HT user	1773	1		1		1757	1		1
Apoe-ε4 − & past HT user	389	0.61 (0.25–1.53)	0.30	0.54 (0.22–1.35)	0.19	387	0.56 (0.17–1.82)	0.34	0.48 (0.15–1.57)	0.23
Apoe-ε4 − & current HT user	371	1.35 (0.52–3.53)	0.54	1.05 (0.41–2.73)	0.92	370	2.01 (0.67–5.97)	0.21	1.45 (0.49–4.32)	0.51
Apoe-ε4 + & never HT user	396	2.33 (1.47–3.71)	<0.001	2.24 (1.41–3.56)	<0.001	389	2.29 (1.30–4.05)	0.004	2.13 (1.20–3.80)	0.01
Apoe-ε4 + & past HT user	98	2.58 (0.92–7.23)	0.07	2.33 (0.83–6.53)	0.11	98	3.24 (0.98–10.7)	0.05	2.54 (0.76–8.53)	0.13
Apoe-ε4 + & current HT user	103	1.13 (0.15–8.39)	0.91	0.87 (0.12–6.52)	0.89	103	2.17 (0.28–16.6)	0.46	1.47 (0.19–11.5)	0.71

^aAdjusted for age, education level, centre, high caffeine consumption, depressive symptoms, physical incapacities, comorbidity, marital status, anticholinergic drugs, body mass index and age at menopause (adjustment was also made for Apoe-ε4 when the association with HT use was examined).