Figure 4. A domain co-occurrence network for known CM domains and their combination partners in human.

Nodes represent domains and each link represents co-occurrence relationship of two domains in proteins. Size of the nodes is proportional to the number of domain-containing proteins in each genome, and nodes are colored red, magenta and green, denoting known CM domains, candidate CM domains and non-CM domains, respectively. The thickness of edges is proportional to the Co-occurrence Score for the linked domain pair (See Materials and Methods for definition of Co-occurrence Score).