Table 1. Selected known CM domains.
| Pfam_Acc | Pfam_id | Function |
| PF00856 | SET | Protein lysine methyltransferase activity |
| PF08123 | DOT1 | H3K79 methyltransferase activity |
| PF02373 | JmjC | Histone demethylase activity [64], [65], [66] |
| PF02375 | JmjN | Together with JmjC, appears histone demethylase |
| PF00628 | PHD | Methylated or unmethylated histone H3 binding |
| PF00385 | Chromo | Methylated histone H3 binding [67], [68] |
| PF00567 | TUDOR | Methylated histone binding [69], [70], [71] |
| PF00855 | PWWP | H4K20me binding [72] |
| PF02820 | MBT | Methylated histone binding [73], [74] |
| PF01853 | MOZ_SAS | Histone acetyltransferase activity |
| PF00583 | Acetyltransf_1 | Acetyltransferase activity, GNAT family |
| PF00850 | Hist_deacetyl | Histone deacetylase activity |
| PF02146 | SIR2 | NAD-dependent histone deacetylase activity |
| PF00439 | Bromodomain | Acetylated histone H3, H4 binding [36], [75] |
| PF03366 | YEATS | Putative histone binding domain [43] |
| PF01426 | BAH | H3, H4 tail binding [76], [77] |
| PF00533 | BRCT | Phosphorylated H2A binding [44], [78] |
| PF00145 | DNA_methylase | DNA-binding, DNA methylase activity |
| PF01429 | MBD | Methylated DNA-binding [45] |
| PF00271 | Helicase_C | ATP binding, helicase activity, nucleic acid binding |
| PF00176 | SNF2_N | DNA-binding, ATP binding |
| PF00249 | Myb_DNA-binding | DNA-binding |
| PF04433 | SWIRM | DNA-binding [79], [80] |
| PF00125 | Histone | DNA-binding |
| PF00538 | Linker_histone | DNA-binding |
A total of 25 Pfam domains occurring in well-documented CM proteins were selected as known CM domains (See the text for details). Function annotations of domains were obtained from the Pfam database whenever available, or from the literature, otherwise. Numbers in parenthesis denote literature references.