Table 2. Systolic blood pressure (SBP), body weight and brain weight of double transgenic rats before and after middle cerebral artery occlusion with reperfusion (MCAOR) or sham intervention; protocol 2 with blood pressure target of 130 mmHg and 7 days of follow-up.

	Sham intervention						MCAOR
	Candesartan			Aliskiren			Candesartan			Aliskiren
N (after intervention)	9			9			12			14
N (at study end)	9			9			11			13
SBP before minipump (mmHg)	177	±	5	180	±	5	187	±	4	182	±	5
SBP before intervention (mmHg)	135	±	3	132	±	4	130	±	4	132	±	3
Weight before minipump (g)	179	±	4	183	±	4	184	±	3	179	±	5
Weight before intervention (g)	214	±	3	219	±	5	220	±	3	222	±	5
Weight 24 h after intervention (g)	211	±	3	215	±	3	194	±	3*	197	±	5*
Weight 48 h after intervention (g)	222	±	3	225	±	3	202	±	3	205	±	7
Weight 7 d after intervention (g)	257	±	4	259	±	5	209	±	14	223	±	10
Brain weight 24 h after intervention (g)	1.82	±	0.01	1.83	±	0.01	1.75	±	0.02	1.78	±	0.02

Differences between the treatment groups (candesartan vs. aliskiren) were not statistically significant. There was no vehicle group in this protocol because untreated animals do not survive 48 h after MCAOR.

Data are means ± standard error of the mean.

The Mann-Whitney-U test was used for comparisons.

*p<0.01 vs. same group before intervention.