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. 2010 Nov 29;5(11):e15111. doi: 10.1371/journal.pone.0015111

Figure 4. RC-101 films do not alter vaginal pH or microbiological profile of the cervicovagina.

Figure 4

(A) Vaginal pH was measured prior to film instillation at days 1-4 (D1-D4) and at followup (D5 and D8). Each measurement represents one experimental condition in a pigtailed macaque. Horizontal lines represent the mean value for all 11 replicates. No differences were observed between monkeys that were receiving RC-101 films or placebo films. (B) represents the difference in vaginal pH between the time zero condition and 30 minutes after film instillation for each day films were applied (D1–D4). Horizontal lines represent the mean value for all 11 replicates. A significant difference was observed at Day 4 (P = 0.003), with the placebo films inducing a greater change in vaginal pH than the RC-101 films. (C) Four (of twenty) microbes are presented for both RC-101 films and placebo films. For each microbe, there are 10 vertical bars, representing the number of replicates (from a total of 11) that were positive for the microbe indicated. The ten bars for each microbe signify the following from left to right: Day 1 (D1) time zero (t0), D1, time 30 min (t30), D2 t0, D2 t30, D3 t0, D3 t30, D4 t0, D4 t30, D5 and D8.