Figure 5. RC-101 was retained in the cervicovagina up to four days post-application.

RC-101 was assessed by quantitative western blot from acetic acid-extracted samples of cervical biopsies, vaginal biopsies and cytobrushes at day 5, and cytobrushes and CVL fluid at day 8 (A). Note that CVL fluid was subdivided into both the cellular portion and the fluid portion. A representative western blot for RC-101 in cytobrushes at day 5 is shown in (B), with “M1”, “M2”, and “M3” signifying three individual monkeys. Note that the same monkey received both RC-101 films and placebo films six weeks apart, and that RC-101 was absent in cytobrushes obtained from monkeys that received placebo films. The P-values presented were adjusted for multiple comparisons using Tukey method.