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. Author manuscript; available in PMC: 2011 Dec 10.
Published in final edited form as: J Mol Biol. 2010 Oct 7;404(4):732–748. doi: 10.1016/j.jmb.2010.09.060

Figure 2.

Figure 2

Schematic depiction of hydrophobic interactions in human PrP. Names of residues that are part of the hydrophobic core (with purely hydrophobic side chains) are shown in black, or, if implicated in disease-causing mutations, in red; other residues involved in the hydrophobic core are shown in gray, or, if implicated in disease-causing mutations, in pink. The blue dashed line indicates interactions between residues in HB and HC and the purple dashed line indicates interactions between HC and the S1-HA loop.