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Signs of early misfolding. Coloring as in Figure 8. Relevant main chain and side chain atoms (in sticks) and hydrogen bond interactions (blue dashed lines) are shown. Side chains of res. P137, I139, F141 and M205, V209, M213 are also shown as transparent spheres. (a) Run 1 of F198S PrP, 32.5 ns. (b) Run 1 of V210I PrP, 40.5 ns. (c) Run 3 of V210I PrP, 39.5 ns.
