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. 2010 Dec 1;24(23):2654–2665. doi: 10.1101/gad.1989110

Figure 4.

Figure 4.

Activation of the ERK pathway results RSK-dependent cell migration. (A) Activation of multiple signaling cascades points to a critical role of the ERK pathway in the migration of MCF10A cells. (B) Treatment of cells with small molecule inhibitors of the ERK/RSK pathway results in suppression of cell migration phenotypes. Inhibitors were used at previously described concentrations: 10 μM U0126, 10 μM BI-D1870, and 100 μM SL0101. (C) Knockdown of RSK1 can significantly attenuate cell migration due to DLG5 knockdown. (D) Immunoblot analysis showing efficacy of RSK1 knockdown upon siRNA treatment.