Table 1.
Clinical and biochemical characteristics of NASH patients and control subjects
| NASH Patients (n = 80) | Control Subjects (n = 80) | P | |
|---|---|---|---|
| Sex (% male) | 63 | 63 | NSa |
| Age (years) | 51 ± 2 | 50 ± 2 | NSa |
| Body mass index (kg/m2) | 27.2 ± 2.3 | 27.0 ± 2.1 | NSa |
| Current smokers (%) | 20 | 23 | 0.73 |
| Waist circumference (cm) | 98 ± 5 | 92 ± 3 | <0.05 |
| Systolic BP (mmHg) | 130 ± 9 | 124 ± 4 | <0.05 |
| Diastolic BP (mmHg) | 84 ± 5 | 81 ± 3 | 0.23 |
| Fasting glucose (mmol/L) | 6.4 ± 1.0 | 5.5 ± 0.3 | <0.05 |
| HOMA insulin resistance score | 4.12 ± 2.0 | 2.78 ± 1.1 | <0.001 |
| Triglycerides (mmol/L) | 1.49 ± 0.8 | 1.15 ± 0.4 | <0.001 |
| HDL cholesterol (mmol/L) | 1.33 ± 0.4 | 1.44 ± 0.3 | <0.05 |
| LDL cholesterol (mmol/L) | 3.17 ± 0.3 | 3.19 ± 0.3 | 0.61 |
| ALT (U/L) | 98 ± 20 | 24 ± 3 | <0.001 |
| GGT (U/L) | 61 ± 20 | 32 ± 4 | <0.001 |
| Metabolic syndrome (%) | 56 | 1.2 | <0.001 |
| Diabetes (%) | 12.5 | 0 | <0.001 |
| Estimated GFR (ml/min per 1.73 m2) | 75.3 ± 12 | 87.5 ± 6 | <0.001 |
| Abnormal albuminuria (%) | 14 | 2.5 | <0.001 |
| Chronic kidney disease (%)b | 25 | 3.7 | <0.001 |
Data are expressed as means ± SD or percentages. ALT, alanine aminotransferase; GGT, gamma-glutamyltransferase; NS, not significant.
a
Matched variables.
b
Chronic kidney disease was defined as abnormal albuminuria (i.e., albumin/creatinine ratio ≥ 30 mg/g) and/or estimated GFR ≤ 60 ml/min per 1.73 m2.