. 2010 Dec;5(12):2172–2179. doi: 10.2215/CJN.07851109

Table 3.

Multivariate Cox regression analysis of factors associated with CKD progression

Demographic Characteristics	Hazard Ratio	95% Confidence Interval
Age (years)
2 to 5	0.72	0.61 to 0.84^a
6 to 12	0.97	0.85 to 1.10
>12	1.00	—
CKD stage
stage II	1.00	—
stage III	2.00	1.64 to 2.42^a
stage IV	6.68	5.46 to 8.18^a
Primary diagnosis
dysplasia	1.15	0.96 to 1.37
reflux nephropathy	0.85	0.68 to 1.06
focal segmental glomerulosclerosis	1.77	1.48 to 2.12^a
other	1.13	0.98 to 1.30
obstructive uropathy	1.00	—
Cohort year
1994 to 1999	0.78	0.69 to 0.88^a
2000 to 2008	1.00	—
Hypertension
yes	1.26	1.14 to 1.40^a
no	1.00	—
Laboratory data at registration
anemia
hematocrit <33%	1.52	1.36 to 1.69^a
hematocrit >33%	1.00	—
calcium
<8.5 mg/dl	1.29	1.06 to 1.58^b
≥8.5 mg/dl	1.00	—
phosphorus (high)
high	1.41	1.25 to 1.59^a
normal	1.00	—
albumin
≤4.0 g/dl	1.67	1.49 to 1.86^a
>4.0 g/dl	1.00	—
Medication use at registration
erythropoietin use
yes	1.30	1.14 to 1.49^c
no	1.00	—
growth hormone use
yes	1.24	1.04 to 1.48^b
no	1.00	—

Factors in the multivariate analysis include age, gender, race, hematocrit, albumin, CKD stage, primary diagnosis, cohort year, calcium, phosphorus, anemia, hypertension, iron supplementation, growth hormone use, and erythropoietin use.

P < 0.0001.

P < 0.05.

P < 0.005.