Table 1.
Characteristics of patients with and without PAD
| All | PAD (−) | PAD (+) | Pa | |
|---|---|---|---|---|
| N | 315 | 240 | 75 | |
| Age (years)b | 60.6 ± 12.7 (28 to 90) | 59.0 ± 12.9 (28 to 89) | 66.1 ± 10.2 (44 to 90) | <0.0001 |
| Percent female | 32.7 | 35.8 | 22.7 | 0.0352 |
| HD vintage (years)b | 9.0 ± 7.9 (0.3 to 22.2) | 9.3 ± 8.0 (0.3 to 22.2) | 8.1 ± 7.6 (0.3 to 19.7) | 0.2384 |
| Diabetes (%) | 31.1 | 22.2 | 59.5 | <0.0001 |
| Current smoking (%) | 41.1 | 35 | 62.7 | <0.0001 |
| Hemoglobin (g/dl)c | 10.3 ± 0.9 (10.21 to 10.43) | 10.3 ± 0.9 (10.18 to 10.42) | 10.4 ± 1.0 (10.16 to 10.61) | 0.5215 |
| Albumin (g/dl)c | 3.9 ± 0.4 (3.84 to 3.92) | 3.9 ± 0.4 (3.86 to 3.95) | 3.8 ± 0.3 (3.73 to 3.90) | 0.0577 |
| Kt/Vc | 1.45 ± 0.26 (1.418 to 1.481) | 1.48 ± 0.27 (1.440 to 1.515) | 1.36 ± 0.21 (1.312 to 1.414) | 0.0019 |
| Tcho (mg/dl)c | 142.5 ± 33.1 (138.75 to 146.28) | 139.7 ± 34.1 (135.29 to 144.15) | 152.0 ± 27.6 (145.30 to 158.64) | 0.0071 |
| HDL cholesterol (mg/dl)c | 45.3 ± 13.7 (43.70 to 46.99) | 46.3 ± 14.2 (44.29 to 48.24) | 42.6 ± 12.0 (39.74 to 45.53) | 0.0593 |
| LDL cholesterol (mg/dl)c | 79.2 ± 22.2 (76.55 to 81.81) | 78.0 ± 22.6 (74.90 to 81.06) | 82.9 ± 20.9 (77.83 to 87.93) | 0.1145 |
| Triglyceride (mg/dl)c | 114.3 ± 85.2 (104.21 to 124.36) | 108.4 ± 82.8 (97.14 to 119.71) | 132.3 ± 90.4 (110.41 to 154.18) | 0.0445 |
| iPTH (pg/ml)c | 234.9 ± 215.1 (209.99 to 259.89) | 238.1 ± 222.0 (208.56 to 267.68) | 224.9 ± 192.8 (178.53 to 271.18) | 0.6559 |
| Adjusted Ca (mg/dl)c | 8.8 ± 0.7 (8.75 to 8.91) | 8.9 ± 0.7 (8.77 to 8.95) | 8.7 ± 0.7 (8.56 to 8.88) | 0.1376 |
| P (mg/dl)c | 5.7 ± 1.2 (5.57 to 5.84) | 5.7 ± 1.1 (5.55 to 5.86) | 5.7 ± 1.3 (5.42 to 6.02) | 0.9047 |
| Ca x P (mg2/dl2)c | 50.4 ± 10.9 (49.09 to 51.62) | 50.5 ± 10.8 (49.09 to 51.97) | 49.8 ± 11.3 (47.10 to 52.53) | 0.6385 |
| Total ALP (U/L)c | 270.4 ± 119.2 (256.55 to 284.21) | 270.7 ± 120.4 (254.66 to 286.73) | 269.4 ± 116.26 (241.45 to 297.30) | 0.9364 |
| baPWV (cm/s)c | 1914.8 ± 639.4 (1840.1 to 1989.5) | 1846.8 ± 590.8 (1761.6 to 1931.9) | 21115.3 ± 733.1 (1969.2 to 2261.4) | 0.0020 |
| Comorbidities (%) | ||||
| hypertension | 79.0 | 76.7 | 86.7 | 0.0738 |
| stroke | 20.6 | 15.9 | 36.0 | 0.0005 |
| CAD | 20.3 | 12.5 | 45.3 | <0.0001 |
| Medication | ||||
| CaCO3 (g/day)b | 1.6 ± 0.9 (0.0 to 4.5) | 1.6 ± 0.9 (0.0 to 3.5) | 1.8 ± 0.9 (0.0 to 4.5) | 0.1042 |
| sevelamer hydrochloride (mg/day)b | 1469 ± 1405 (0 to 7500) | 1364 ± 1286 (0 to 7500) | 1757 ± 1666 (0 to 7500) | 0.1098 |
| ACE-I/ARB (%) | 33.7 | 32.5 | 37.3 | 0.4845 |
| statin (%) | 21.3 | 20.4 | 24.0 | 0.5201 |
| aspirin (%) | 69.8 | 69.2 | 72.0 | 0.6686 |
| clostazol (%) | 5.1 | 2.9 | 12.0 | 0.0042 |
| ticlopidine (%) | 12.4 | 7.1 | 29.3 | <0.0001 |
| prostaglandin E (%) | 5.4 | 2.1 | 16.0 | <0.0001 |
HD, hemodialysis; Tcho, total cholesterol; iPTH, intact parathyroid hormone; P, phosphate; Ca, calcium; ALP, alkaline phosphatase; ACE-I, angitensin converting enzyme inhibitor; ARB, angiotensin receptor blocker.
a
PAD (−) verus PAD (+).
b
Mean ± SD (range).
c
Mean ± SD (95% confidence interval).