Figure 3.

Kaplan-Meier estimates of time to first clinical event. Clinical events included cardiac events (myocardial infarction, significant cardiac procedure, arrhythmia, angina, or congestive heart failure), cerebrovascular events (strokes), renal events (chronic dialysis, renal transplant, or eGFR < 10 ml/min per 1.73 m²), or death. Clinical events may have occurred either while patients were enrolled in the Fabry Registry or before enrollment, if such events were recorded on patients' medical history case report forms. Note that clinical data from patients in this cohort were restricted to data obtained before any chronic dialysis or renal transplant. Six men and one woman subsequently experienced renal events, and these are included in the Kaplan-Meier analysis. Patients were stratified by gender and baseline eGFR, as indicated in A–D. Data for patients with averaged UP/Cr ≥ 0.5 who experienced a clinical event during the natural history period are shown in dark gray, and data for patients with averaged UP/Cr < 0.5 are shown in light gray. The numbers of patients at risk for having events at the indicated ages are shown below the x-axis for each panel.