Table 1.
Demographic data across quartiles of phosphate adjusted for eGFR
| N = 1203, Mean (SD), n (%), Median (range) | All | First Quartile, n = 275 | Second Quartile, n = 345 | Third Quartile, n = 320 | Fourth Quartile, n = 263 | P |
|---|---|---|---|---|---|---|
| Age (years) | 64 (14) | 66 (13) | 65 (14) | 64 (13) | 61 (15) | <0.0005 |
| Female gender | 427 (36%) | 74 (27%) | 114 (33%) | 126 (40%) | 113 (43%) | <0.0005 |
| eGFR (ml/min per 1.73 m2) | 32 (15) | 32 (15) | 32 (15) | 31 (15) | 33 (16) | 0.561 |
| Corr. calcium (mmol/L) | 2.29 (0.14) | 2.28 (0.13) | 2.30 (0.15) | 2.28 (0.14) | 2.30 (0.15) | 0.119 |
| Phosphate (mmol/L) | 1.2 (0.31) (0.45 to 3.47) | 0.9 (0.17) (0.45 to 1.38) | 1.1 (0.16) (0.83 to 1.67) | 1.3 (0.20) (0.99 to 1.98) | 1.5 (0.32) (1.08 to 3.47) | <0.0001 |
| PTH (pg/ml) normal range 10 to 65 | 89 (1 to 1019) | 87 (4 to 677) | 88 (2 to 699) | 95 (3 to 1019) | 87 (1 to 488) | 0.683 |
| Hemoglobin (g/L) | 124 (17) | 130 (17) | 125 (18) | 122 (15) | 120 (17) | <0.0005 |
| Proteinuria (grams per day) | 1.1 (0 to 16.2) | 0.8 (0.05 to 8.9) | 0.8 (0.05 to 14.9) | 1.3 (0.1 to 16.2) | 1.5 (0 to 15.1) | <0.0005 |
| CVD | 379 (32%) | 93 (34%) | 119 (35%) | 105 (33%) | 62 (23%) | 0.015 |
| DM | 383 (32%) | 80 (29%) | 93 (27%) | 118 (37%) | 92 (35%) | 0.022 |
| SBP (mmHg) | 139 (22) | 141 (21) | 138 (21) | 140 (22) | 138 (24) | 0.338 |
| DBP (mmHg) | 76 (13) | 76 (13) | 76 (12) | 77 (13) | 76 (13) | 0.771 |
| PP | 63 (19) | 65 (19) | 62 (18) | 64 (19) | 63 (22) | 0.279 |
| Weight (kg) | 81 (18) | 85 (20) | 82 (17) | 79 (19) | 77 (17) | <0.0005 |
| BMI | 28 (6) | 29 (7) | 29 (5) | 28 (6) | 27 (6) | 0.003 |
| Current smoker | 156 (13%) | 18 (7%) | 37 (11%) | 52 (16%) | 49 (19%) | <0.0005 |
| Ever smoked | 832 (69%) | 190 (69%) | 242 (70%) | 209 (66%) | 191 (72%) | 0.363 |
| All binders | 90 (8%) | 16 (6%) | 17 (5%) | 24 (8%) | 33 (13%) | 0.003 |
| Non-Ca phosphate binders | 11 (1%) | 2 (0.7%) | 1 (0.3%) | 4 (1.3%) | 4 (1.5%) | 0.387 |
| Calcium-containing phosphate binders | 81 (7%) | 15 (6%) | 16 (5%) | 20 (6%) | 30 (12%) | 0.007 |
| Vitamin D analogs | 199 (17%) | 47 (17%) | 63 (18%) | 52 (16%) | 37 (14%) | 0.607 |
PTH, parathyroid hormone; CaxP, calcium × phosphate product; CVD, cardiovascular disease; DM, diabetes; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; BMI, body mass index; Non-Ca, non–calcium containing.