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. Author manuscript; available in PMC: 2011 Mar 19.
Published in final edited form as: J Control Release. 2009 Nov 17;142(3):332–338. doi: 10.1016/j.jconrel.2009.11.007

Figure 3.

Figure 3

Arterial ultrastructure determines drug distribution. Control or atherosclerotic arteries were incubated for 24h in fluorescent drug, serial sectioned and either analyzed for compositional distribution or imaged en face using a fluorescent microscope to determine drug distribution. (a,e) oil-red-O stain for lipid. (b,f) tubulin immunostain in brown; (c,g) VerHoeff stain shows elastin as black wavy lines; (d,h) fluorescent paclitaxel deposition (green). Diet and injury decreased total elastin and tubulin levels by 40±5% and 37±5%, respectively. Concomitantly, total fluorescent paclitaxel deposition dropped 73±9% and total lipid levels increased by 28±7%.