Table 2. Combination index (CI) and dose reduction index (DRI) values for vorinostat and 5′-deoxy-5-fluorouridine (5′-DFUR) combination treatment.
|
DRI at IC50 ±s.d.
|
||||
|---|---|---|---|---|
| Cell lines | CI50 ±s.d. vorinostat + 5′-DFURa | CI75 ±s.d vorinostat + 5′-DFURa | Vorinostat | 5′-DFURb |
| LoVo | 0.78±0.13 | 0.76±0.1 | 2.3±1 | 4.4±2 |
| LS174T | 0.69±0.09 | 0.6±0.2 | 1.4±0.7 | 2±0.5 |
| SW620 | 0.76±0.1 | 0.57±0.23 | 3.1±0.8 | 2.3±0.2 |
a
CI values (mean±s.d. from at least three separate experiments performed in quadruplicates) computed at 50 and 75% of cell kill (CI50 and CI75, respectively) according by CalcuSyn software after 96 h of treatment. Combinations were considered strongly synergistic when CIs were below 0.9.
b
DRI values (mean±s.d. from at least three separate experiments performed in quadruplicates) represents the order of magnitude (fold) of dose reduction obtained for IC50 (DRI50) in combination setting compared with each drug alone.