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. Author manuscript; available in PMC: 2010 Nov 30.
Published in final edited form as: Eur J Immunol. 2009 Aug;39(8):2281–2292. doi: 10.1002/eji.200838985

Figure 3. Reduced gelatinolytic and collagenolytic activities in the lungs of mice depleted of Gr-1+ cells.

Figure 3

Mice received DO Th1 + Th2 cells followed by anti-Gr-1 or isotype control mAb and were challenged with the low dose of OVA. 12 h (A, C) or 24 h (B, D) after antigen challenge, lung sections were overlaid with fluorescently labeled DQ gelatin (A, B) or DQ collagen type I (C, D). (Magnification 10X) The relative intensities of gelatinolytic (E) or collagenolytic (F) activities in the lungs of mice (3 mice per data point) 24 h after PBS or OVA challenge (B and D) were quantified using the ImageJ software. Data represent means ± SEM, (*p<0.05, vs. groups treated with control mAb). Data shown are representative of 3 independent experiments.