Table II.
Genotypes distribution of the DEC1 polymorphisms among SCCHN cases and cancer-free controls and their associations with SCCHN risk
| Genotypes | Cases, No. (%) | Controls, No. (%) | P value | Crude OR (95% CI) | Adjusted OR (95% CI)a |
| All subjects | 1111 (100.0) | 1130 (100.0) | |||
| DEC1 −1628 G>C (rs1591420) | 0.526b | ||||
| GG | 1008 (91.8) | 1021 (91.6) | 1.00 | 1.00 | |
| CG | 89 (8.1) | 90 (08.1) | 1.00 (0.74–1.36) | 1.03 (0.75–1.42) | |
| CC | 1 (0.1) | 4 (0.4) | 0.25 (0.03–2.27) | 0.33 (0.03–3.16) | |
| CG + CC | 90 (8.2) | 94 (8.4) | 0.842c | 0.97 (0.72–1.31) | 1.00 (0.73–1.37) |
| C allele frequency | 0.041 | 0.044 | 0.680d | ||
| DEC1 −606 T>C (rs4978620)f | 0.267e | ||||
| TT | 529 (47.7) | 537 (47.5) | 1.00 | 1.00 | |
| CT | 492 (44.3) | 481 (42.6) | 1.04 (0.87–1.24) | 0.95 (0.79–1.14) | |
| CC | 89 (08.0) | 112 (09.9) | 0.81 (0.60–1.09) | 0.71 (0.52–0.99) | |
| TT + CT | 1021 (92.0) | 1018 (90.1) | 0.117c | 0.79 (0.59–1.06) | 0.73 (0.54–0.99) |
| C allele frequency | 0.302 | 0.312 | 0.462d | ||
| DEC1 T>C (Ala→Val, rs2269700) | 0.127e | ||||
| TT | 403 (37.7) | 429 (38.8) | 1.00 | 1.00 | |
| CT | 522 (48.8) | 499 (45.2) | 1.11 (0.93–1.34) | 1.11 (0.92–1.35) | |
| CC | 144 (13.5) | 177 (16.0) | 0.87 (0.67–1.12) | 0.87 (0.66–1.14) | |
| TT + CT | 925 (86.5) | 928 (84.0) | 0.094c | 0.82 (0.64–1.04) | 0.82 (0.64–1.05) |
| C allele frequency | 0.379 | 0.386 | 0.629d | ||
| DEC1 G>A (rs3750505) | 0.731e | ||||
| GG | 859 (78.2) | 882 (78.9) | 1.00 | 1.00 | |
| AG | 221 (20.1) | 222 (19.9) | 1.02 (0.83–1.26) | 1.10 (0.88–1.36) | |
| AA | 18 (1.7) | 11 (1.2) | 1.32 (0.65–2.67) | 1.46 (0.70–3.03) | |
| AG + AA | 239 (21.8) | 236 (21.1) | 0.706c | 1.04 (0.85–1.27) | 1.12 (0.90–1.38) |
| A allele frequency | 0.117 | 0.112 | 0.585d | ||
| TP53 Arg72Pro (rs1042522 G>C) | 0.307e | ||||
| GG | 576 (54.7) | 617 (54.6) | 1.00 | 1.00 | |
| CG | 398 (37.8) | 445 (39.4) | 0.96 (0.80–1.14) | 0.96 (0.79–1.15) | |
| CC | 80 (07.6) | 68 (06.0) | 1.26 (0.90–1.78) | 1.28 (0.89–1.83) | |
| C allele frequency | 0.265 | 0.257 | 0.566c |
Statistically significant results (P < 0.05) are highlighted in bold.
a
ORs were obtained from logistic regression models with adjustment for age, sex, smoking and alcohol status.
b
Fisher’s exact test for the distribution of three genotypes.
c
Two-sided χ2 test for distribution of combined genotypes.
d
Two-sided χ2 test for allele difference between cases and controls.
e
Two-sided χ2 test for the distribution of three genotypes.
f
SNP rs4978620 was in complete linkage disequilibrium with rs4978620 and rs2012566.