Table III.
Stratification analysis of the association between DEC1 -249 T > C SNP and SCCHN risk
| Variables |
DEC1 (rs4978620 T>C) |
|||||||
| (Cases/Controls) |
Pa | OR (95% CI) |
PIntc | |||||
| TT+CT |
CC |
TT+CT (ref) versus CC |
||||||
| No. | % | No. | % | Crude | Adjustedb | |||
| All subjects | 1021/1018 | 92.0/90.1 | 89/112 | 8.0/9.9 | 0.117 | 0.79 (0.59–1.06) | 0.73 (0.54–0.99) | |
| Age (median) | 0.796 | |||||||
| ≤57 | 548/527 | 92.6/89.6 | 44/61 | 7.4/10.4 | 0.076 | 0.69 (0.46–1.04) | 0.63 (0.41–0.97) | |
| >57 | 437/491 | 91.3/90.6 | 45/51 | 8.7/9.4 | 0.682 | 0.92 (0.60–1.40) | 0.89 (0.56–1.40) | |
| Sex | 0.991 | |||||||
| Female | 255/249 | 93.1/92.2 | 19/21 | 6.9/7.8 | 0.706 | 0.88 (0.46–1.68) | 0.62 (0.31–1.26) | |
| Male | 766/769 | 91.6/89.4 | 70/91 | 8.4/10.6 | 0.121 | 0.77 (0.56–1.07) | 0.76 (0.54–1.06) | |
| Smoking status | ||||||||
| Never | 293/503 | 95.4/91.0 | 14/50 | 4.6/9.0 | 0.016 | 0.48 (0.26–0.89) | 0.48 (0.26–0.89) | |
| Former | 348/367 | 91.3/89.1 | 33/45 | 8.7/10.9 | 0.286 | 0.77 (0.48–1.24) | 0.80 (0.49–1.29) | 0.433 |
| Current | 380/148 | 90.0/89.7 | 42/17 | 10.0/10.3 | 0.899 | 0.96 (0.53–1.74) | 0.96 (0.52–1.78) | 0.176 |
| Drinking status | ||||||||
| Never | 284/440 | 93.4/89.1 | 20/54 | 6.6/10.9 | 0.040 | 0.57 (0.34–0.98) | 0.55 (0.32–0.95) | |
| Former | 222/161 | 91.7/88.9 | 20/20 | 8.3/11.1 | 0.333 | 0.73 (0.38–1.39) | 0.64 (0.33–1.26) | 0.677 |
| Current | 515/417 | 91.3/91.6 | 49/38 | 8.7/8.4 | 0.849 | 1.04 (0.67–1.63) | 0.95 (0.59–1.53) | 0.495 |
| TP53 (codon 72) | 0.070 | |||||||
| Arg/Arg | 537/557 | 93.2/90.3 | 39/60 | 6.8/9.6 | 0.065 | 0.64 (0.44–1.03) | 0.61 (0.39–0.94) | |
| Arg/Pro+ Pro/Pro | 431/461 | 90.4/89.9 | 46/52 | 9.6/10.1 | 0.795 | 0.95 (0.62–1.44) | 0.89 (0.57–1.40) | |
| Tumor site | — | |||||||
| Oral cavity | 295/1018 | 91.3/90.1 | 28/112 | 8.7/9.9 | 0.504 | 0.86 (0.56–1.33) | 0.87 (0.55–1.40) | |
| Oropharynx | 521/1018 | 93.2/90.1 | 38/112 | 6.8/9.9 | 0.034 | 0.66 (0.45–0.97) | 0.64 (0.43–0.95) | |
| Hypopharynx + larynx | 196/1018 | 90.7/90.1 | 20/112 | 9.3/9.9 | 0.768 | 0.93 (0.56–1.53) | 0.85 (0.49–1.49) | |
| TNM stage | — | |||||||
| I | 108/1018 | 90.8/90.1 | 11/112 | 9.2/9.9 | 0.816 | 0.93 (0.48–1.77) | 0.91 (0.47–1.77) | |
| II | 143/1018 | 91.1/90.1 | 14/112 | 8.9/9.9 | 0.694 | 0.89 (0.50–1.59) | 0.91 (0.50–1.67) | |
| III | 173/1018 | 91.0/90.1 | 17/112 | 9.0/9.9 | 0.679 | 0.89 (0.52–1.53) | 0.85 (0.49–1.49) | |
| IV | 596/1018 | 92.7/90.1 | 47/112 | 7.3/9.9 | 0.065 | 0.72 (0.50–1.02) | 0.68 (0.47–0.98) | |
| Nodal stage | ||||||||
| N0 | 372/1018 | 91.4/90.1 | 35/112 | 8.6/9.9 | 0.440 | 0.86 (0.58–1.23) | 0.82 (0.54–1.26) | |
| N1–3 | 648/1018 | 92.3/90.1 | 54/112 | 7.7/9.9 | 0.108 | 0.76 (0.54–1.06) | 0.71 (0.50–1.01) | |
| Tumor stage | ||||||||
| T1–2 | 623/1018 | 91.3/90.1 | 59/112 | 8.7/9.9 | 0.374 | 0.86 (0.62–1.20) | 0.83 (0.59–1.17) | |
| T3–4 | 397/1018 | 93.0/90.1 | 30/112 | 7.0/9.9 | 0.078 | 0.69 (0.45–1.05) | 0.64 (0.41–1.01) | |
Statistically significant results (P < 0.05) are highlighted in bold.
a
P value of the comparison with a two-sided χ2 test.
b
ORs were obtained from a logistic regression model with adjustment for age, sex, smoking and alcohol status accordingly.
c
Pint: P value of a chi-square test for the cross product of two variables with adjustment for age, sex, smoking and drinking status in the logistic regression model.