Table 1.

Previous studies have implicated epigenetic mechanisms in hearing loss.

Disease	Epigenetic Mechanism	Gene Involved	Reference
Vestibular Schwannoma	DNA Methylation	CASP8	Lassaletta et al., 2006
	Histone Acetylation	RASSF1A	Kino et al., 2001
		NF2	Hirokawa et al., 2005
Retinoblastoma	DNA methylation	Rb	Sage et al., 2006
			Lohmann et al., 1997
Rett Syndrome	DNA Methylation	MeCP2	Buschdorf et al., 2004
Oculo-oto-radial syndrome	Unknown	Unknown	Elcioglu et al 1997
Stickler Syndrome	Methylcytosine deamination	COL2A1 COL11A1	Wilkin et al., 2000
Facioscapulohumeral	DNA	D4Z4	van Overveld et al., 2003
Muscular dystrophy	Hypomethylation	repeat array
Immunodeficiency-centromeric	DNA	DNMT3b	Braegger et al., 1991
instability-facial anomalies syndrome	Hypomethylation		Stacey et al., 1995
Beckwith-Wiedemann syndrome	Imprinting Error	KCNQ1OT1	Weksberg et al., 2002
			Murrell et al., 2004
CHARGE syndrome	Histone Acetylation?	CHD7?	Tong et al., 1998