Table 5. Drug transporters and metabolizing enzymes.
| Full name | Symbol | Entrez Gene ID | Log2 R |
|---|---|---|---|
| Over-represented genes in iHCE | |||
| Solute carrier F. 2 (facilitated glucose transporter), M. 10 | SLC2A10 | 81031 | 3.81 |
| Solute carrier F. 7 (cationic amino acid transporter, y+ system), M. 5 | SLC7A5 | 8140 | 3.61 |
| Solute carrier F. 22 (organic cation/ergothioneine transporter), M. 4 | SLC22A4 | 6583 | 3.00 |
| ATP-binding cassette, sub-F. G (WHITE), M. 2 | ABCG2 | 9429 | 2.60 |
| Transporter 1, ATP-binding cassette, sub-F. B (MDR/TAP) | TAP1 | 6890 | 2.08 |
| Cytochrome P450, F. 1, sub-F B, polypeptide 1 | CYP1B1 | 1545 | 1.88 |
| ATP-binding cassette, sub-F. B (MDR/TAP), M. 7 | ABCB7 | 22 | 1.83 |
| ATP-binding cassette, sub-F. C (CFTR/MRP), M. 4 | ABCC4 | 10257 | 1.67 |
| ATP-binding cassette, sub-F. C (CFTR/MRP), M. 3 | ABCC3 | 8714 | 1.56 |
| ATP-binding cassette, sub-F. B (MDR/TAP), M. 1 | ABCB1 | 5243 | 1.54 |
| Solute carrier F. 1 (glial high affinity glutamate transporter), M. 3 | SLC1A3 | 6507 | 1.52 |
| Solute carrier F. 16, M. One (monocarboxylic acid transporter 1) | SLC16A1 | 6566 | 1.40 |
| Solute carrier F. 2 (facilitated glucose transporter), M. 3 | SLC2A3 | 6515 | 1.32 |
| Solute carrier F. 15, M. 3 | SLC15A3 | 51296 | 1.19 |
| Solute carrier F. 2 (facilitated glucose transporter), M. 6 | SLC2A6 | 11182 | 0.89 |
| Solute carrier F. 2 (facilitated glucose transporter), M. 8 | SLC2A8 | 29988 | 0.80 |
| Full name | Symbol | Entrez Gene ID | -Log2 R |
| Under-represented genes in iHCE | |||
| Solute carrier F. 7 (cationic amino acid transporter, y+ system), M. 8 | SLC7A8 | 23428 | 3.24 |
| Solute carrier F. 2 (facilitated glucose transporter), M. 1 | SLC2A1 | 6513 | 2.16 |
| Solute carrier F. 22, M. 14 | SLC22A14 | 9389 | 1.68 |
| Solute carrier F. 2 (facilitated glucose/fructose transporter), M. 5 | SLC2A5 | 6518 | 1.67 |
| ATP-binding cassette, sub-F. B (MDR/TAP), M. 6 | ABCB6 | 10058 | 1.38 |
| ATP-binding cassette, sub-F. C (CFTR/MRP), M. 5 | ABCC5 | 10057 | 1.37 |
| ATP-binding cassette, sub-F. G (WHITE), M. 1 | ABCG1 | 9619 | 1.29 |
| Cytochrome P450, family 2, sub-F. C, polypeptide 18 | CYP2C18 | 1562 | 1.26 |
| ATP-binding cassette, sub-F. C (CFTR/MRP), M. 8 | ABCC8 | 6833 | 1.15 |
| Cytochrome P450, family 2, sub-F. C, polypeptide 19 | CYP2C19 | 1557 | 1.01 |
| Solute carrier F. 2 (facilitated glucose transporter), M. 9 | SLC2A9 | 56606 | 1.01 |
| Solute carrier F. 22, M. 17 | SLC22A17 | 51310 | 0.99 |
| Solute carrier F. 6 (proline IMINO transporter), M. 20 | SLC6A20 | 54716 | 0.83 |
| Cystic fibrosis transmemb. conductance regulator (ABC sub-F. C, M. 7) | CFTR | 1080 | 0.73 |
| Cytochrome P450, family 2, sub-F. C, polypeptide 9 | CYP2C9 | 1559 | 0.70 |
| Solute carrier F. 5 (sodium/glucose cotransporter), M. 1 | SLC5A1 | 6523 | 0.66 |
| Cytochrome P450, F. 1, sub-F. A, polypeptide 2 | CYP1A2 | 1544 | 0.66 |
| Solute carrier F. 22 (organic anion/urate transporter), M. 11 | SLC22A11 | 55867 | 0.61 |
| Solute carrier F. 6 (neurotransmitter transporter, betaine/GABA), M. 12 | SLC6A12 | 6539 | 0.57 |
| Solute carrier F. 7 (cationic amino acid transporter, y+ system), M. 4 | SLC7A4 | 6545 | 0.52 |
| Solute carrier F. 16, M. Four (monocarboxylic acid transporter 5) | SLC16A4 | 9122 | 0.49 |
In the table, F indicates family and M indicates member.