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. 2010 Aug 24;17(Suppl 1):S12. doi: 10.1186/1423-0127-17-S1-S12

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Copyright ©2010 Taranukhin et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of taurine on ethanol-induced apoptosis in the developing cerebellum (A) Number of activated caspase-3 immunoreactive Purkinje cells in the cerebellar lobules of 4-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm² with standard deviations. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of caspase-3 immunoreactive cells in all lobules. There were no significant differences between the ethanol and ethanol+taurine groups. (B) Number of apoptotic Purkinje cells (labeled by TUNEL assay) in the cerebellar lobules of 4-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm² with standard deviations. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of TUNEL-positive Purkinje cells in all lobules. There were no significant differences between the ethanol and ethanol+taurine groups. (C) Number of activated caspase-3-immunoreactive cells in the IGL in the cerebellar lobules of 7-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm² with standard deviations. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of caspase-3 immunoreactive cells in all lobules. The significance of differences between the ethanol and ethanol+taurine groups: *P<0.05.(D) The number of apoptotic cells (labeled by TUNEL assay) in the IGL in the cerebellar lobules of 7-day-old mice in the control (open bars), ethanol-treated (filled bars) and ethanol+taurine-treated (hatched bars) mice. The results are given per mm² with standard deviation. Number of animals in each group is 5. Ethanol significantly (P<0.01) increased the number of TUNEL-positive cells in all lobules. The significance of differences between the ethanol and ethanol+taurine groups: *P<0.05.