Table 1.
The demographics and clinical characteristics of enrolled patients (n = 435)
| Patients without HCC (n = 329) | Patients with HCC (n = 106) | p value | |
|---|---|---|---|
| Age (years, mean ± SD) | 51.0 ± 11.8 | 61.8 ± 11.8 | <0.001 |
| Gender (%) | <0.001 | ||
| Male | 203 (61.7) | 84 (79.2) | |
| Female | 126 (38.3) | 22 (20.8) | |
| Etiology (%) | <0.001 | ||
| HBV | 87 (26.4) | 44 (41.5) | |
| HCV | 213 (64.7) | 35 (33) | |
| HBV + HCV | 19 (5.8) | 9 (8.5) | |
| Non-B/non-C | 10 (3.0) | 18 (17) | |
| Liver cirrhosis (%) | 74 (22)a | 80 (75.5)b | <0.001 |
| BMI (kg/m2) | 24.2 ± 3.4 | 23.6 ± 3.5 | 0.110 |
| AST (u/l) | 87.5 ± 67.8 | 86.9 ± 67.6 | 0.944 |
| ALT (u/l) | 123.2 ± 111.8 | 76.2 ± 75.9 | <0.001 |
| Platelet (×103/mm3) | 180.6 ± 65.0 | 172.7 ± 111.4 | 0.371 |
| APRI | 1.6 ± 1.5 | 2.0 ± 2.4 | 0.028 |
| Bilirubin (mg/dl) | 1.02 ± 0.88 | 1.63 ± 4.39 | 0.018 |
| AFP (ng/ml, %) | <0.001 | ||
| <200 | 316 (96) | 83 (78.3) | |
| ≥200 | 13 (4) | 23 (21.7) | |
| Stiffness (kPa) | 11.2 ± 8.9 | 26.7 ± 22.5 | <0.001 |
| Log stiffness (kPa) | 0.96 ± 0.26 | 1.27 ± 0.38 | <0.001 |
HBV hepatitis B virus, HCC hepatocellular carcinoma, HCV hepatitis C virus, Non-B/Non-C etiology outside from HBV or HCV, BMI body-mass index, AST aspartate aminotransferase, ALT alanine aminotransferase, APRI AST–platelet ratio index, AFP alpha-fetoprotein
aConfirmed by pathology
bDiagnosis with images including ultrasonography and/or computed tomography