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. 2010 Oct 1;17(12):827–836. doi: 10.1038/cgt.2010.38

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Copyright © 2010 Nature America, Inc.

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Cell growth was inhibited in HPV-positive cervical cancer cells by HPV-siRNAs. A total of 1 × 10⁶ cells (Caski or HeLa or C33A) were seeded into a 100-mm² dish. After transfection of a specific HPV-siRNA, cell numbers were counted every day for up to 3 days. (a) Differential inhibition of cell growth by HPV-16E6-siRNAs in Caski cells. (b) Differential inhibition of cell growth by HPV-16E7-siRNAs in Caski cells. (c) Differential inhibition of cell growth by HPV-18E6-siRNAs in HeLa cells. (d) Differential inhibition of cell growth by HPV-18E7-siRNAs in HeLa cells. (e) Minimal effect of cell growth by HPV-16-siRNAs in non-HPV-infected C33A cells. (f) Minimal effect of cell growth by HPV-18-siRNAs in non-HPV-infected C33A cells.