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. 2010 Nov 30;8(11):e1000547. doi: 10.1371/journal.pbio.1000547

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Platelet-rich human plasma was incubated with different concentrations of AnSt-D7L1 for 1 min prior to the addition of agonists as indicated. Aggregation was measured at 37°C on an aggregometer. Unless otherwise stated protein concentration (µM) is shown under respective curves. (A) Concentration dependence of AnSt-D7L1 inhibition of collagen-mediated platelet aggregation at low concentration of collagen. (B) Lack of inhibition of collagen-mediated platelet aggregation by AnSt-D7L1 at high concentration of collagen. (C) Lack of inhibition of convulxin-mediated platelet aggregation by AnSt-D7L1. (D) ADP-mediated platelet aggregation in the absence of any protein (control), in the presence of 3 µM AnSt-D7L1, or in the presence of 3 µM RPAI1, which is known to bind ADP. (E) Lack of effect of AnSt-D7L1 on PMA-induced platelet aggregation. (F) Lack of effect of AnSt-D7L1 on ristocetin-induced platelet aggregation.